SCHEMBL21333447

SCHEMBL21333447

Brc1ccc2c(Br)occ2c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 3/20 0.39
ALDH1A1 P00352 2/20 0.37
KDM4E B2RXH2 1/20 0.37
MEN1 O00255 1/20 0.37
MAPT P10636 1/20 0.37
KMT2A Q03164 1/20 0.37
ERN1 O75460 1/20 0.35
AHR P35869 4/20 0.34
NR4A2 P43354 1/20 0.34
TDP2 O95551 1/20 0.33
CDC25B P30305 1/20 0.33
CASP6 P55212 1/20 0.33
PPP1CA P62136 1/20 0.33
PTPN1 P18031 1/20 0.33
PLAU P00749 1/20 0.33
METAP2 P50579 2/20 0.32
PIM1 P11309 1/20 0.32
BACE1 P56817 1/20 0.32
NOS1 P29475 1/20 0.32
CSNK2A1 P68400 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31267442 0.82 CYP2A6 (0.39) CYP2A6ALDH1A1KDM4EMEN1MAPT
SCHEMBL30510787 0.78 CYP1A2 (0.37) CYP2A6AHRPTPN1BACE1APP
SCHEMBL2092077 0.78 CYP2A6 (0.37) CYP2A6ALDH1A1KDM4EMEN1MAPT
SCHEMBL27488106 0.74 APAF1 (0.36) CYP2A6MEN1MAPTKMT2ATDP2
SCHEMBL9998180 0.74 KIF11 (0.36) ALDH1A1MAPTPIM1BACE1
SCHEMBL155366 0.74 ERN1 (0.38) CYP2A6ALDH1A1KDM4EMEN1MAPT
SCHEMBL7633234 0.72 PIM1 (0.45) CYP2A6ALDH1A1KDM4EMEN1MAPT
SCHEMBL10966532 0.72 TAAR1 (0.33) ALDH1A1KDM4EMEN1MAPTKMT2A
SCHEMBL11684409 0.71 MAOA (0.43) CYP2A6ALDH1A1MEN1MAPTKMT2A
SCHEMBL30095448 0.71 MAPT (0.42) ALDH1A1MEN1MAPTKMT2APTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023165581-A1 PYRIDINE DERIVATIVE AND USE THEREOF 四川汇宇制药股份有限公司 2023-09-07 WO disclosed
EP-3761978-A1 INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5), PHARMACEUTICAL PRODUCTS THEREOF, AND METHODS THEREOF PHARMABLOCK SCIENCES (NANJING), INC. (CN) 2021-01-13 EP disclosed
WO-2019173804-A1 INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5), PHARMACEUTICAL PRODUCTS THEREOF, AND METHODS THEREOF PHARMABLOCK SCIENCES (NANJING), INC. (CN) 2019-09-12 WO disclosed
CN-109071498-A Kinase inhibitor and preparation method and application thereof 四川科伦博泰生物医药股份有限公司 2018-12-21 CN disclosed