Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 14/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | VNN1 | O95497 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18436930 | 0.86 | POLB (0.39) | EGLN1POLBMAPTPDCD1CD274 | |
| SCHEMBL18436545 | 0.85 | MTNR1A (0.39) | EGLN1PDCD1CD274 | |
| SCHEMBL18436729 | 0.84 | CD274 (0.43) | EGLN1PDCD1CD274 | |
| SCHEMBL18436737 | 0.82 | KDM4E (0.46) | EGLN1POLB | |
| SCHEMBL18436681 | 0.82 | GSK3B (0.38) | POLBMAPTPDCD1CD274 | |
| SCHEMBL21336708 | 0.79 | HTR1A (0.36) | EGLN1PDCD1CD274 | |
| SCHEMBL18436862 | 0.79 | EGLN1 (0.36) | EGLN1PDCD1CD274 | |
| SCHEMBL18436919 | 0.79 | EGLN1 (0.36) | EGLN1PDCD1CD274 | |
| SCHEMBL18436682 | 0.78 | RAD52 (0.38) | EGLN1 | |
| SCHEMBL18436859 | 0.77 | TP53 (0.44) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-B1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO LTD (CN) | 2019-09-11 | — | — | EP | disclosed |