Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | APLNR | P35414 | 1/20 | 0.35 |
| ▸ | PRPS1 | P60891 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 2/20 | 0.32 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20200677 | 0.81 | PIK3CD (0.42) | PIK3CAPIK3CDPIK3CBPIK3CGMAPK14 | |
| SCHEMBL18988775 | 0.78 | PIK3CA (0.42) | PIK3CAPIK3CDPIK3CBPIK3CGMAPK14 | |
| SCHEMBL21338955 | 0.75 | HTR2C (0.45) | — | |
| SCHEMBL21338957 | 0.74 | SLC6A4 (0.47) | — | |
| SCHEMBL21339365 | 0.69 | QDPR (0.43) | APLNRSUV39H2 | |
| SCHEMBL20777092 | 0.69 | PDE3B (0.41) | PIK3CAPIK3CDPIK3CBPIK3CGMAPK14 | |
| SCHEMBL23419706 | 0.69 | TPH1 (0.39) | PIK3CAPIK3CDPIK3CBPIK3CGMAPK14 | |
| SCHEMBL2457641 | 0.66 | PIK3CA (0.41) | PIK3CAPIK3CDPIK3CBPIK3CGMAPK14 | |
| SCHEMBL20777090 | 0.66 | PIK3CD (0.36) | PIK3CAPIK3CDPIK3CBPIK3CGMAPK14 | |
| SCHEMBL24377637 | 0.65 | PIM1 (0.43) | PIK3CAPIK3CDPIK3CBPIK3CGMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10736883-B2 | Triazole furan compounds as agonists of the APJ receptor | AMGEN INC. (US) | 2020-08-11 | — | — | US | disclosed |
| US-20190275008-A1 | TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2019-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190275008-A1 | TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | TBXA2R, AGTR1, APLNR | PIK3CA 1901/4885PIK3CD 1806/4885PIK3CB 2158/4885 |
| US-10736883-B2 | Triazole furan compounds as agonists of the APJ receptor | TBXA2R, AGTR1, APLNR | PIK3CA 1901/4885PIK3CD 1806/4885PIK3CB 2158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.