Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.45 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22845074 | 0.83 | GABRA1 (0.48) | GABRA1GABRB2LMNAALOX15ALOX12 | |
| SCHEMBL9204057 | 0.82 | GABRA1 (0.59) | GABRA1GABRB2LMNAHTTTAAR1 | |
| SCHEMBL45861 | 0.78 | GABRA1 (0.68) | GABRA1GABRB2FEN1ALOX15ALOX12 | |
| SCHEMBL10430788 | 0.74 | LMNA (0.41) | GABRA1GABRB2LMNATP53HTT | |
| SCHEMBL22589011 | 0.73 | LMNA (0.35) | LMNATP53HTTTAAR1 | |
| Hydrochloric Acid SCHEMBL5092759 | 0.72 | LMNA (0.34) | LMNATP53HTTTAAR1 | |
| Iodide SCHEMBL5026630 | 0.72 | LMNA (0.34) | LMNATP53HTTTAAR1 | |
| Bromide SCHEMBL5088439 | 0.72 | LMNA (0.34) | LMNATP53HTTTAAR1 | |
| Water SCHEMBL9711083 | 0.72 | LMNA (0.34) | LMNATP53HTTTAAR1 | |
| SCHEMBL27932018 | 0.72 | GABRA1 (0.41) | GABRA1GABRB2FEN1ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019173639-A1 | MACROCYCLIC LIGANDS WITH PENDANT CHELATING MOIETIES AND COMPLEXES THEREOF | LUMIPHORE, INC. (US) | 2019-09-12 | — | — | WO | disclosed |