Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | RECQL | P46063 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL487169 | 0.80 | GABRA1 (0.56) | LMNATSHRHIF1ABLMADRB2 | |
| SCHEMBL9614891 | 0.80 | ADRB2 (0.39) | LMNATSHRHIF1ABLMADRB2 | |
| SCHEMBL135746 | 0.79 | LMNA (0.50) | LMNARECQLTDP1KDM4EMAPT | |
| SCHEMBL24217828 | 0.78 | ADRB2 (0.42) | LMNARECQLTDP1KDM4ETSHR | |
| SCHEMBL30046916 | 0.78 | ADRB2 (0.42) | LMNARECQLTDP1KDM4ETSHR | |
| SCHEMBL2989000 | 0.78 | ADRB2 (0.42) | LMNARECQLTDP1KDM4ETSHR | |
| SCHEMBL21343570 | 0.74 | GABRA1 (0.45) | LMNATSHRALOX15TP53HTT | |
| SCHEMBL3916363 | 0.74 | ADRA2A (0.40) | LMNARECQLTDP1ALOX15HSD17B10 | |
| SCHEMBL27991485 | 0.73 | MCL1 (0.37) | TDP1TSHRALOX15HSD17B10TP53 | |
| SCHEMBL2382143 | 0.73 | TSHR (0.57) | TSHRALOX15HSD17B10ADRB2ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0400478-A2 | Branched polycarbonates and method of preparation | GENERAL ELECTRIC COMPANY (US) | 1990-12-05 | — | — | EP | disclosed |
| EP-0378858-A2 | Process for the preparation of branched thermoplastic polycarbonates | GENERAL ELECTRIC COMPANY (US) | 1990-07-25 | — | — | EP | disclosed |