Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TFPI2 | P48307 | 5/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.44 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.44 |
| ▸ | PPM1B | O75688 | 2/20 | 0.41 |
| ▸ | PPP5C | P53041 | 2/20 | 0.39 |
| ▸ | PPP2CA | P67775 | 1/20 | 0.39 |
| ▸ | NPY4R | P50391 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9880144 | 1.00 | TFPI2 (0.45) | TFPI2CHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL9880141 | 0.83 | TFPI2 (0.56) | TFPI2PPM1BPPP5CPPP2CANPY4R | |
| SCHEMBL20459524 | 0.83 | TFPI2 (0.46) | TFPI2CHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL13001974 | 0.83 | CHRNB2 (0.43) | TFPI2CHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL14135612 | 0.82 | TFPI2 (0.46) | TFPI2PPM1BPPP5CPPP2CANPY4R | |
| SCHEMBL19177682 | 0.82 | TSHR (0.40) | TFPI2CHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL9880146 | 0.81 | TFPI2 (0.60) | TFPI2PPM1BPPP5CPPP2CANPY4R | |
| SCHEMBL16451149 | 0.78 | PPM1B (0.45) | TFPI2PPM1BPPP5CPPP2CANPY4R | |
| SCHEMBL9880153 | 0.77 | HSD11B1 (0.45) | TFPI2PPM1BPPP5CPPP2CANPY4R | |
| SCHEMBL9880150 | 0.75 | TFPI2 (0.73) | TFPI2CHRNB2CHRNA3CHRNA4CHRNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10413541-B2 | Oxabicycloheptanes and oxabicycloheptenes for the treatment of depressive and stress disorders | LIXTE BIOTECHNOLOGY, INC. (US) | 2019-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10413541-B2 | Oxabicycloheptanes and oxabicycloheptenes for the treatment of depressive and stress disorders | HSD17B11, HSD17B1, CRH | TFPI2 4289/4885CHRNB2 743/4885CHRNA3 787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.