Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLYCD | O95822 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17894222 | 0.89 | MLYCD (0.42) | MLYCDHSP90AA1HSP90AB1HPGDMEN1 | |
| SCHEMBL256775 | 0.88 | MLYCD (0.41) | MLYCDHSP90AA1HSP90AB1HPGDMEN1 | |
| SCHEMBL18348146 | 0.83 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1HPGDMEN1KMT2A | |
| SCHEMBL25257215 | 0.81 | MLYCD (0.36) | MLYCDHSP90AA1HSP90AB1HPGDMEN1 | |
| SCHEMBL2272338 | 0.81 | MLYCD (0.45) | MLYCDHPGDMEN1KMT2AHTT | |
| SCHEMBL17893862 | 0.81 | TSHR (0.46) | MLYCDHSP90AA1HSP90AB1HPGDMEN1 | |
| SCHEMBL26566639 | 0.80 | MLYCD (0.36) | MLYCDHSP90AA1HSP90AB1HPGDMEN1 | |
| SCHEMBL589423 | 0.79 | MLYCD (0.48) | MLYCDHPGDMEN1KMT2AHTT | |
| SCHEMBL3706341 | 0.79 | MEN1 (0.58) | MLYCDHSP90AA1HSP90AB1HPGDMEN1 | |
| SCHEMBL25256351 | 0.79 | MLYCD (0.38) | MLYCDHSP90AA1HSP90AB1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12018011-B2 | Macrocyclic compounds and compositions, and methods of preparing and using the same | KURA ONCOLOGY, INC. (US) | 2024-06-25 | — | — | US | disclosed |
| US-20230322711-A1 | MACROCYCLIC COMPOUNDS AND COMPOSITIONS, AND METHODS OF PREPARING AND USING THE SAME | WUXI APPTEC (HONG KONG) LIMITED (CN) | 2023-10-12 | — | — | US | disclosed |
| US-20220106323-A1 | SPIROCYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. | 2022-04-07 | — | — | US | disclosed |
| US-20220106329-A1 | BICYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B V (US) | 2022-04-07 | — | — | US | disclosed |
| US-11242350-B2 | Spirocyclic ROR-gamma modulators | ESCALIER BIOSCIENCES B.V. (US) | 2022-02-08 | — | — | US | disclosed |
| US-11230555-B2 | Bicyclic RORγ modulators | ESCALIER BIOSCIENCES B.V. (US) | 2022-01-25 | — | — | US | disclosed |
| US-20210053987-A1 | BICYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. | 2021-02-25 | — | — | US | disclosed |
| US-20210053976-A1 | SPIROCYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. | 2021-02-25 | — | — | US | disclosed |
| CN-112292124-A | Bicyclic ROR-gamma modulators | 爱思凯利尔生物科学私人有限责任公司 | 2021-01-29 | — | — | CN | disclosed |
| CN-112118841-A | Spirocyclic ROR-gamma modulators | 爱思凯利尔生物科学私人有限责任公司 | 2020-12-22 | — | — | CN | disclosed |
| WO-2019177997-A1 | SPIROCYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. (US) | 2019-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11242350-B2 | Spirocyclic ROR-gamma modulators | RORA, RORC, RORB | MLYCD 4092/4885HSP90AA1 854/4885HSP90AB1 830/4885 |
| US-12018011-B2 | Macrocyclic compounds and compositions, and methods of preparing and using the same | FNTA, FDPS, GGPS1 | MLYCD 1364/4885HSP90AA1 2438/4885HSP90AB1 2585/4885 |
| US-20230322711-A1 | MACROCYCLIC COMPOUNDS AND COMPOSITIONS, AND METHODS OF PREPARING AND USING THE SAME | FNTA, FDPS, GGPS1 | MLYCD 1364/4885HSP90AA1 2438/4885HSP90AB1 2585/4885 |
| US-11230555-B2 | Bicyclic RORγ modulators | RORC, RORA, RORB | MLYCD 3627/4885HSP90AA1 1901/4885HSP90AB1 1680/4885 |
| US-20210053987-A1 | BICYCLIC ROR-GAMMA MODULATORS | RORA, RORC, RORB | MLYCD 3583/4885HSP90AA1 1903/4885HSP90AB1 1768/4885 |
| US-20220106323-A1 | SPIROCYCLIC ROR-GAMMA MODULATORS | RORA, RORC, RORB | MLYCD 4092/4885HSP90AA1 854/4885HSP90AB1 830/4885 |
| US-20210053976-A1 | SPIROCYCLIC ROR-GAMMA MODULATORS | RORA, RORC, RORB | MLYCD 4180/4885HSP90AA1 649/4885HSP90AB1 693/4885 |
| US-20220106329-A1 | BICYCLIC ROR-GAMMA MODULATORS | RORA, RORC, RORB | MLYCD 3583/4885HSP90AA1 1903/4885HSP90AB1 1768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.