Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | CNR2 | P34972 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20157796 | 0.88 | SRD5A2 (0.43) | KMT2ACNR2RAB9AMAPTSRD5A2 | |
| SCHEMBL20157564 | 0.85 | LMNA (0.42) | KMT2AHPGDMEN1SMN1; SMN2 | |
| SCHEMBL8008483 | 0.81 | MAPK1 (0.53) | KMT2ACNR2RAB9AMAPTSRD5A2 | |
| SCHEMBL10599055 | 0.81 | SRD5A2 (0.54) | KMT2ARAB9AMAPTSRD5A2NR4A1 | |
| SCHEMBL21564711 | 0.80 | ALDH1A1 (0.43) | KMT2ARAB9AMAPTPOLBMAPK1 | |
| SCHEMBL20157798 | 0.78 | MAPT (0.50) | KMT2ARAB9AMAPTSRD5A2NR4A1 | |
| SCHEMBL21362792 | 0.76 | ALDH1A1 (0.44) | KMT2AMAPTHPGDMEN1 | |
| SCHEMBL27707316 | 0.76 | L3MBTL1 (0.42) | KMT2APOLBHPGDMEN1 | |
| SCHEMBL20157488 | 0.75 | HTT (0.49) | KMT2ARAB9AMAPTMAPK1HPGD | |
| SCHEMBL21564942 | 0.74 | MKNK1 (0.36) | RAB9APOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3539960-A1 | NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | Luoxin Pharmaceutical (Shanghai) Co., Ltd. (CN) | 2019-09-18 | — | — | EP | disclosed |