Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.48 |
| ▸ | FEN1 | P39748 | 1/20 | 0.48 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27475261 | 0.86 | PIN1 (0.68) | PIN1MAPK1HSD17B10USP2TSHR | |
| SCHEMBL28582964 | 0.84 | TARBP2 (0.54) | PIN1MAPK1HSD17B10USP2TSHR | |
| SCHEMBL6520020 | 0.83 | PIN1 (0.52) | PIN1MAPK1HSD17B10USP2TSHR | |
| SCHEMBL28575489 | 0.80 | DGAT1 (0.49) | PIN1MAPK1HSD17B10USP2TSHR | |
| SCHEMBL15592594 | 0.80 | HSD17B10 (0.56) | PIN1MAPK1HSD17B10USP2TSHR | |
| SCHEMBL15442034 | 0.77 | HSD17B10 (0.59) | PIN1MAPK1HSD17B10USP2TSHR | |
| SCHEMBL7989862 | 0.77 | AR (0.54) | TARBP2ALDH1A1MAPTLMNARAB9A | |
| SCHEMBL28914603 | 0.77 | AR (0.54) | TARBP2ALDH1A1MAPTLMNARAB9A | |
| SCHEMBL9893863 | 0.76 | PIN1 (0.56) | PIN1TARBP2ALDH1A1HPGDSIRT2 | |
| SCHEMBL6258083 | 0.76 | ADORA3 (0.53) | PIN1MAPK1HSD17B10USP2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3230277-B1 | SUBSTITUTED HETEROCYCLES AS BROMODOMAIN INHIBITORS | ZENITH EPIGENETICS LTD (CA) | 2019-09-18 | — | — | EP | disclosed |