Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.49 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10794853 | 0.74 | IDO1 (0.44) | KDRPDK1CA1CA2CA7 | |
| Ethylene SCHEMBL28056951 | 0.74 | LMNA (0.40) | KDRPDK1CA1CA2CA7 | |
| SCHEMBL14303602 | 0.73 | NOTUM (0.49) | KDRPDK1HTR3EHTR3BHTR3A | |
| SCHEMBL11503126 | 0.71 | KDR (0.50) | KDRPDK1CA1CA2CA7 | |
| SCHEMBL24766925 | 0.70 | NPFFR2 (0.50) | KDRPDK1CA1CA2CA7 | |
| SCHEMBL10656533 | 0.69 | KDR (0.56) | KDRPDK1CA1CA2CA7 | |
| SCHEMBL11473055 | 0.69 | LMNA (0.47) | KDRGRM4BRAFNOTUMHTT | |
| SCHEMBL25745990 | 0.69 | NOTUM (0.43) | KDRHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL27624474 | 0.69 | HTR3E (0.41) | KDRPDK1CA1CA2CA7 | |
| SCHEMBL11743617 | 0.68 | KDR (0.61) | KDRPDK1CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230391734-A1 | SUBSTITUTED PHENYL SULFONYL PHENYL TRIAZOLE THIONES AND USES THEREOF | NEUROPORE THERAPIES, INC. (US) | 2023-12-07 | — | — | US | disclosed |
| US-11708338-B2 | Substituted phenyl sulfonyl phenyl triazole thiones and uses thereof | NEUROPORE THERAPIES, INC. (US) | 2023-07-25 | — | — | US | disclosed |
| US-20210300881-A1 | SUBSTITUTED PHENYL SULFONYL PHENYL TRIAZOLE THIONES AND USES THEREOF | NEUROPORE THERAPIES, INC. (US) | 2021-09-30 | — | — | US | disclosed |
| US-20210290597-A1 | METHOD OF TREATING A CONDITION ASSOCIATED WITH NEURODEGENERATION USING INHIBITORS OF OAT3 | NEUROPORE THERAPIES, INC. (US) | 2021-09-23 | — | — | US | disclosed |
| US-11008294-B2 | Substituted phenyl sulfonyl phenyl triazole thiones and uses thereof | NEUROPORE THERAPIES, INC. (US) | 2021-05-18 | — | — | US | disclosed |
| EP-3810133-A1 | METHOD OF TREATING A CONDITION ASSOCIATED WITH NEURODEGENERATION USING INHIBITORS OF OAT3 | Neuropore Therapies, Inc. (US) | 2021-04-28 | — | — | EP | disclosed |
| EP-3703675-A1 | SUBSTITUTED PHENYL SULFONYL PHENYL TRIAZOLE THIONES AND USES THEREOF | Neuropore Therapies, Inc. (US) | 2020-09-09 | — | — | EP | disclosed |
| US-20200123116-A1 | SUBSTITUTED PHENYL SULFONYL PHENYL TRIAZOLE THIONES AND USES THEREOF | NEUROPORE THERAPIES, INC. (US) | 2020-04-23 | — | — | US | disclosed |
| US-20190292158-A1 | SUBSTITUTED PHENYL SULFONYL PHENYL TRIAZOLE THIONES AND USES THEREOF | NEUROPORE THERAPIES, INC. (US) | 2019-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210300881-A1 | SUBSTITUTED PHENYL SULFONYL PHENYL TRIAZOLE THIONES AND USES THEREOF | TPMT, ABCB1, DPP8 | KDR 3512/4885PDK1 580/4885CA1 4486/4885 |
| US-11008294-B2 | Substituted phenyl sulfonyl phenyl triazole thiones and uses thereof | TPMT, ABCB1, DPP8 | KDR 3512/4885PDK1 580/4885CA1 4486/4885 |
| US-20210290597-A1 | METHOD OF TREATING A CONDITION ASSOCIATED WITH NEURODEGENERATION USING INHIBITORS OF OAT3 | OAT, CLN6, SLC2A3 | KDR 4532/4885PDK1 3401/4885CA1 1527/4885 |
| US-20190292158-A1 | SUBSTITUTED PHENYL SULFONYL PHENYL TRIAZOLE THIONES AND USES THEREOF | TPMT, ABCB1, DPP8 | KDR 3512/4885PDK1 580/4885CA1 4486/4885 |
| US-11708338-B2 | Substituted phenyl sulfonyl phenyl triazole thiones and uses thereof | TPMT, ABCB1, DPP8 | KDR 3512/4885PDK1 580/4885CA1 4486/4885 |
| US-20230391734-A1 | SUBSTITUTED PHENYL SULFONYL PHENYL TRIAZOLE THIONES AND USES THEREOF | TPMT, ABCB1, DPP8 | KDR 3512/4885PDK1 580/4885CA1 4486/4885 |
| US-20200123116-A1 | SUBSTITUTED PHENYL SULFONYL PHENYL TRIAZOLE THIONES AND USES THEREOF | TPMT, ABCB1, DPP8 | KDR 3512/4885PDK1 580/4885CA1 4486/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.