Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTPS1 | P17812 | 10/20 | 0.32 |
| ▸ | CNR2 | P34972 | 5/20 | 0.32 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21373811 | 0.82 | CTPS1 (0.48) | CTPS1 | |
| SCHEMBL21387636 | 0.79 | CTPS1 (0.39) | CTPS1 | |
| SCHEMBL23121390 | 0.79 | ALDH1A1 (0.34) | POLBALDH1A1SYK | |
| SCHEMBL21373756 | 0.78 | AAK1 (0.38) | POLBALDH1A1SYKAAK1 | |
| SCHEMBL21392165 | 0.73 | ACACB (0.39) | — | |
| SCHEMBL21387693 | 0.73 | SYK (0.43) | CTPS1SYK | |
| SCHEMBL21373726 | 0.72 | CTPS1 (0.45) | CTPS1 | |
| SCHEMBL21392033 | 0.71 | LMNA (0.40) | CNR2CNR1ALDH1A1SYKGPR119 | |
| SCHEMBL21387600 | 0.70 | CTPS1 (0.31) | CTPS1SYK | |
| SCHEMBL24895507 | 0.70 | ALDH1A1 (0.39) | POLBALDH1A1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3543232-A1 | AMINOPYRIMIDINE DERIVATIVES AS CTPS1 INHIBITORS | Step Pharma S.A.S. (FR) | 2019-09-25 | — | — | EP | disclosed |