Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | NPR3 | P17342 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.30 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.30 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21373773 | 0.81 | CTPS1 (0.46) | — | |
| SCHEMBL21387717 | 0.80 | ALDH1A1 (0.35) | ALDH1A1NPSR1 | |
| SCHEMBL24895775 | 0.78 | LMNA (0.43) | LMNAKMT2AALDH1A1NPR3ATR | |
| SCHEMBL29791248 | 0.78 | LMNA (0.43) | LMNAKMT2AALDH1A1NPR3ATR | |
| SCHEMBL21373731 | 0.78 | LMNA (0.51) | LMNAKMT2AALDH1A1NPR3ATR | |
| SCHEMBL21392238 | 0.77 | ALDH1A1 (0.32) | KMT2AALDH1A1NPSR1 | |
| SCHEMBL21392146 | 0.73 | CTPS1 (0.32) | — | |
| SCHEMBL21392165 | 0.72 | ACACB (0.39) | ATR | |
| SCHEMBL21387698 | 0.71 | HTR3A (0.32) | — | |
| SCHEMBL21387636 | 0.71 | CTPS1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019180244-A1 | AMINOPYRIMIDINE DERIVATIVES AS CTPS1 INHIBITORS | STEP PHARMA S.A.S. (FR) | 2019-09-26 | — | — | WO | disclosed |
| WO-2019179652-A1 | AMINOPYRIMIDINE DERIVATIVES AS CTPS1 INHIBITORS | STEP PHARMA S.A.S. (FR) | 2019-09-26 | — | — | WO | disclosed |