Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | IDH2 | P48735 | 1/20 | 0.32 |
| ▸ | CTPS1 | P17812 | 4/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21387600 | 0.84 | CTPS1 (0.31) | SYKCTPS1 | |
| SCHEMBL21387636 | 0.78 | CTPS1 (0.39) | CTPS1 | |
| SCHEMBL21392081 | 0.77 | TAS2R14 (0.40) | SYKHRH4HRH3 | |
| SCHEMBL84117 | 0.77 | SYK (0.48) | SYKGSK3BIDH1IDH2CTSK | |
| SCHEMBL84157 | 0.73 | SYK (0.50) | SYK | |
| SCHEMBL15181307 | 0.73 | CTSK (0.56) | SYKGSK3BCTSKHRH4 | |
| SCHEMBL21392118 | 0.72 | CTSK (0.59) | IDH1CTSK | |
| SCHEMBL19171094 | 0.71 | MAPK1 (0.57) | SYKHRH4 | |
| SCHEMBL24650224 | 0.69 | SYK (0.47) | SYKIDH1IDH2HRH4 | |
| SCHEMBL21387698 | 0.69 | HTR3A (0.32) | CTPS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3543232-A1 | AMINOPYRIMIDINE DERIVATIVES AS CTPS1 INHIBITORS | Step Pharma S.A.S. (FR) | 2019-09-25 | — | — | EP | disclosed |