Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 5/20 | 0.38 |
| ▸ | ATF4 | P18848 | 8/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23332748 | 0.81 | MAPT (0.39) | SCN9AATF4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28430157 | 0.69 | RAB9A (0.51) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL28071638 | 0.69 | RXFP1 (0.56) | NPC1RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL28433205 | 0.68 | SMN1; SMN2 (0.70) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL740617 | 0.68 | MGAM (0.56) | SMN1; SMN2MAPTL3MBTL1HDAC1HDAC2 | |
| SCHEMBL23332818 | 0.66 | ATF4 (0.42) | SCN9AATF4MAPTL3MBTL1HDAC1 | |
| SCHEMBL5625543 | 0.66 | GRM2 (0.47) | SCN9AMAPTHDAC1HDAC2 | |
| SCHEMBL8298139 | 0.65 | CNR2 (0.49) | NPC1RAB9ASMN1; SMN2MAPTHDAC1 | |
| SCHEMBL28896405 | 0.64 | CNR1 (0.60) | SCN9AATF4NPC1RAB9AL3MBTL1 | |
| SCHEMBL3133343 | 0.64 | HSD17B14 (0.50) | SCN9ANPC1RAB9ASMN1; SMN2SCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183589-A1 | MODULATORS OF EUKARYOTIC INITIATION FACTOR 2 | DENALI THERAPEUTICS INC. (US) | 2019-09-26 | — | — | WO | disclosed |