Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 3/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 5/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.32 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.32 |
| ▸ | GPR6 | P46095 | 2/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21390670 | 0.91 | TRPV4 (0.35) | IDH1TLR7TLR8TRPV4ACSS2 | |
| SCHEMBL21390678 | 0.85 | TRPV4 (0.32) | TLR7TLR8TRPV4ACSS2PTGDR2 | |
| SCHEMBL21390801 | 0.84 | PTGDR2 (0.36) | IDH1TLR7TLR8TRPV4ACSS2 | |
| SCHEMBL21391043 | 0.83 | ACSS2 (0.41) | TLR7TLR8TRPV4ACSS2PTGDR2 | |
| SCHEMBL21391032 | 0.83 | — | — | |
| SCHEMBL21390806 | 0.82 | PTGDR2 (0.35) | TRPV4ACSS2PTGDR2 | |
| SCHEMBL21390676 | 0.80 | — | — | |
| SCHEMBL30315570 | 0.80 | IDH1 (0.37) | IDH1TRPV4ACSS2GPR6 | |
| SCHEMBL21354579 | 0.80 | IDH1 (0.37) | IDH1TRPV4ACSS2GPR6 | |
| SCHEMBL21391059 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |