Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 8/20 | 0.35 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.31 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.31 |
| ▸ | CCR9 | P51686 | 2/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21390813 | 0.91 | IDH1 (0.33) | TRPV4ACSS2TLR8TLR7IDH1 | |
| SCHEMBL21390678 | 0.88 | TRPV4 (0.32) | TRPV4ACSS2TLR8TLR7SLC22A12 | |
| SCHEMBL21391043 | 0.86 | ACSS2 (0.41) | TRPV4ACSS2TLR8TLR7SLC22A12 | |
| SCHEMBL21390801 | 0.85 | PTGDR2 (0.36) | TRPV4ACSS2TLR8TLR7IDH1 | |
| SCHEMBL21390895 | 0.84 | GPR119 (0.31) | — | |
| SCHEMBL21390806 | 0.83 | PTGDR2 (0.35) | TRPV4ACSS2CYP11B2PTGDR2 | |
| SCHEMBL21390884 | 0.83 | BRD4 (0.33) | IDH1 | |
| SCHEMBL21390794 | 0.81 | — | — | |
| SCHEMBL21390930 | 0.81 | HDAC3 (0.30) | — | |
| SCHEMBL21354597 | 0.78 | TRPV4 (0.38) | TRPV4ACSS2IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |