Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.34 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | IDH1 | O75874 | 1/20 | 0.30 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
| ▸ | GPR6 | P46095 | 1/20 | 0.30 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CCR9 | P51686 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21391043 | 0.92 | ACSS2 (0.41) | PTGDR2TRPV4ACSS2TLR8TLR7 | |
| SCHEMBL21390806 | 0.92 | PTGDR2 (0.35) | PTGDR2TRPV4ACSS2CYP11B1CYP11B2 | |
| SCHEMBL21390670 | 0.85 | TRPV4 (0.35) | PTGDR2TRPV4ACSS2CYP11B2IDH1 | |
| SCHEMBL21390678 | 0.84 | TRPV4 (0.32) | PTGDR2TRPV4ACSS2CYP11B1CYP11B2 | |
| SCHEMBL21390813 | 0.84 | IDH1 (0.33) | PTGDR2TRPV4ACSS2IDH1TLR8 | |
| SCHEMBL21390957 | 0.82 | NTRK1 (0.33) | ACSS2HCRTR1HCRTR2 | |
| SCHEMBL21390797 | 0.82 | PTGDR2 (0.31) | PTGDR2 | |
| SCHEMBL21390799 | 0.82 | PTGDR2 (0.31) | PTGDR2 | |
| SCHEMBL21390959 | 0.81 | TRPV4 (0.39) | TRPV4CYP11B1CYP11B2IDH1 | |
| SCHEMBL21390800 | 0.81 | TRPV4 (0.39) | TRPV4CYP11B1CYP11B2IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |