Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 11/20 | 0.35 |
| ▸ | JAK2 | O60674 | 5/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 7/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 2/20 | 0.34 |
| ▸ | CDK9 | P50750 | 2/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21354577 | 0.79 | EGFR (0.36) | — | |
| SCHEMBL21390870 | 0.76 | JAK1 (0.30) | JAK1 | |
| SCHEMBL21390761 | 0.75 | AR (0.43) | HCAR1JAK1JAK2AURKAPRKCA | |
| SCHEMBL21391122 | 0.66 | CDK9 (0.51) | HCAR1JAK1JAK2AURKAPRKCA | |
| SCHEMBL21390775 | 0.66 | JAK1 (0.38) | HCAR1JAK1JAK2AURKAPRKCA | |
| SCHEMBL21354724 | 0.66 | EGFR (0.33) | — | |
| SCHEMBL17033108 | 0.66 | HCAR1 (0.48) | HCAR1JAK1JAK2AURKAPRKCA | |
| SCHEMBL17586640 | 0.65 | CYP11B2 (0.58) | HCAR1L3MBTL1CDK9CCNT1KDM4E | |
| SCHEMBL21390686 | 0.64 | HCAR1 (0.40) | HCAR1JAK1JAK2AURKAPRKCA | |
| SCHEMBL12791679 | 0.61 | CDK9 (0.57) | HCAR1JAK1JAK2AURKAPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |