Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | LITAF | Q99732 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 2/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.33 |
| ▸ | SSTR1 | P30872 | 2/20 | 0.32 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.32 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.32 |
| ▸ | GRK6 | P43250 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21354685 | 0.82 | EGFR (0.42) | TNFLITAFIDH1EGFRSSTR1 | |
| SCHEMBL21354627 | 0.77 | EGFR (0.41) | TNFLITAFIDH1HCRTR2HCRTR1 | |
| SCHEMBL21391029 | 0.75 | PLA2G1B (0.33) | OPRM1OPRD1OPRK1OGFRL1MAPT | |
| SCHEMBL21390679 | 0.74 | TNF (0.36) | TNFLITAFIDH1MGLLHCRTR2 | |
| SCHEMBL21390891 | 0.73 | TNF (0.36) | TNFLITAFIDH1MGLLHCRTR2 | |
| SCHEMBL21354604 | 0.71 | EGFR (0.40) | HCRTR2HCRTR1EGFROPRM1OPRD1 | |
| SCHEMBL21391028 | 0.69 | MAPT (0.30) | MAPT | |
| SCHEMBL21390924 | 0.67 | HTR3A (0.34) | TNFLITAF | |
| SCHEMBL21354583 | 0.66 | EGFR (0.35) | IDH1EGFR | |
| SCHEMBL17586619 | 0.65 | EGFR (0.52) | EGFROPRM1OPRD1OPRK1OGFRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |