Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.35 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 7/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | APLNR | P35414 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21391063 | 0.89 | HDAC1 (0.36) | HDAC1ACSS2 | |
| SCHEMBL21391060 | 0.89 | HDAC1 (0.36) | HDAC1ACSS2 | |
| SCHEMBL21391169 | 0.88 | BRD4 (0.38) | HDAC1IDH1 | |
| SCHEMBL21391035 | 0.85 | HDAC1 (0.35) | HDAC1IDH1 | |
| SCHEMBL21391170 | 0.83 | KDM2B (0.33) | ACSS2POLBSMN1; SMN2APLNR | |
| SCHEMBL20110998 | 0.81 | EGFR (0.38) | ACSS2IDH1SOS1 | |
| SCHEMBL18791662 | 0.81 | EGFR (0.38) | ACSS2IDH1SOS1 | |
| SCHEMBL18791659 | 0.81 | EGFR (0.38) | ACSS2IDH1SOS1 | |
| SCHEMBL21390781 | 0.80 | BRD4 (0.33) | SMN1; SMN2APLNR | |
| SCHEMBL21390669 | 0.80 | CYP11B2 (0.39) | HDAC1ACSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |