Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.33 |
| ▸ | ACSS2 | Q9NR19 | 2/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CPT1A | P50416 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21391063 | 1.00 | HDAC1 (0.36) | HDAC1CYP11B2ACSS2CYP19A1CYP11B1 | |
| SCHEMBL21391036 | 0.89 | HDAC1 (0.35) | HDAC1ACSS2 | |
| SCHEMBL21390669 | 0.87 | CYP11B2 (0.39) | HDAC1CYP11B2ACSS2CYP19A1CYP11B1 | |
| SCHEMBL21391061 | 0.85 | ACSS2 (0.33) | HDAC1ACSS2 | |
| SCHEMBL21391066 | 0.85 | HDAC1 (0.35) | HDAC1CYP11B2CYP19A1CYP11B1 | |
| SCHEMBL21391163 | 0.84 | CYP19A1 (0.32) | HDAC1CYP11B2ACSS2CYP19A1CYP11B1 | |
| SCHEMBL21391169 | 0.82 | BRD4 (0.38) | HDAC1 | |
| SCHEMBL21391034 | 0.81 | TNKS (0.32) | HDAC1ACSS2CPT1ARORC | |
| SCHEMBL21391155 | 0.81 | ACSS2 (0.39) | HDAC1CYP11B2ACSS2CYP11B1TBXA2R | |
| SCHEMBL21391172 | 0.81 | ACSS2 (0.33) | HDAC1ACSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |