Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 15/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.33 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21391130 | 0.87 | CYP11B2 (0.38) | CYP11B2PDE10APIK3CAMTORPDE2A | |
| SCHEMBL21390713 | 0.86 | CYP11B2 (0.36) | CYP11B2TP53ALDH1A1TSHRHSD17B10 | |
| SCHEMBL21391073 | 0.83 | PDE10A (0.37) | CYP11B2PDE10APIK3CAMTORPDE2A | |
| SCHEMBL21391072 | 0.81 | PDE10A (0.34) | CYP11B2PDE10AALDH1A1PIK3CAMTOR | |
| SCHEMBL21391123 | 0.81 | CYP11B1 (0.39) | CYP11B2TP53ALDH1A1TSHRHSD17B10 | |
| SCHEMBL21391124 | 0.81 | HTR3E (0.35) | CYP11B2PDE10AALDH1A1TSHRHSD17B10 | |
| SCHEMBL21391070 | 0.81 | CYP11B2 (0.36) | CYP11B2PDE10APIK3CAMTORPDE2A | |
| SCHEMBL21390941 | 0.80 | CYP11B2 (0.33) | CYP11B2PDE10APIK3CAMTOR | |
| SCHEMBL16084166 | 0.77 | CYP11B2 (0.39) | CYP11B2PDE10ATP53ALDH1A1PIK3CA | |
| SCHEMBL21390950 | 0.74 | CYP11B2 (0.36) | CYP11B2PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |