Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 9/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.32 |
| ▸ | HTR3B | O95264 | 1/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.32 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21391130 | 0.89 | CYP11B2 (0.38) | PDE10ACYP11B2PIK3CAMTOR | |
| SCHEMBL21391133 | 0.88 | CYP11B1 (0.33) | CYP11B2ALDH1A1ACSS2TNKSPARP2 | |
| SCHEMBL21391073 | 0.87 | PDE10A (0.37) | PDE10ACYP11B2PIK3CAMTOR | |
| SCHEMBL21390955 | 0.85 | ALDH1A1 (0.32) | ALDH1A1ACSS2 | |
| SCHEMBL21391134 | 0.84 | RORC (0.33) | ALDH1A1ACSS2TNKSPARP1PARP2 | |
| SCHEMBL21390764 | 0.83 | CYP11B1 (0.35) | CYP11B2ALDH1A1ACSS2 | |
| SCHEMBL21391070 | 0.82 | CYP11B2 (0.36) | PDE10ACYP11B2PIK3CAMTOR | |
| SCHEMBL21390952 | 0.82 | RORC (0.34) | ALDH1A1ACSS2TNKSPARP1PARP2 | |
| SCHEMBL21391131 | 0.81 | CYP11B2 (0.37) | PDE10ACYP11B2ALDH1A1PIK3CAMTOR | |
| SCHEMBL20624369 | 0.80 | ADRB2 (0.37) | PDE10ACYP11B2CNR1CNR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |