Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 2/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21390711 | 0.86 | CYP11B2 (0.32) | ALDH1A1CYP11B2GRM2SMN1; SMN2 | |
| SCHEMBL21391073 | 0.83 | PDE10A (0.37) | PDE10ACYP11B2PIK3CAMTOR | |
| SCHEMBL21391070 | 0.82 | CYP11B2 (0.36) | PDE10ACYP11B2PIK3CAMTOR | |
| SCHEMBL21391002 | 0.82 | CYP11B1 (0.34) | ALDH1A1CYP11B2IDH1SMN1; SMN2MEN1 | |
| SCHEMBL21391130 | 0.81 | CYP11B2 (0.38) | PDE10ACYP11B2PIK3CAMTOR | |
| SCHEMBL21391131 | 0.81 | CYP11B2 (0.37) | PDE10AALDH1A1TSHRCYP11B2HSD17B10 | |
| SCHEMBL21391120 | 0.79 | TBXA2R (0.35) | HTR1AALDH1A1CYP1A2GRM2USP2 | |
| SCHEMBL16084178 | 0.78 | CDK5 (0.43) | HTR3EHTR3BHTR1AHTR3AHTR3D | |
| SCHEMBL21391072 | 0.76 | PDE10A (0.34) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL21390941 | 0.74 | CYP11B2 (0.33) | PDE10ACYP11B2PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |