Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 4/20 | 0.39 |
| ▸ | TNKS | O95271 | 4/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21390805 | 0.85 | TNKS (0.35) | ACSS2TNKSPARP2PARP1HDAC1 | |
| SCHEMBL21391133 | 0.85 | CYP11B1 (0.33) | ACSS2TNKSPARP2CYP11B1CYP11B2 | |
| SCHEMBL21390668 | 0.83 | HDAC1 (0.35) | ACSS2TNKSPARP2PARP1HDAC1 | |
| SCHEMBL21390952 | 0.83 | RORC (0.34) | ACSS2TNKSPARP2PARP1ENPP2 | |
| SCHEMBL21390770 | 0.81 | ALDH1A1 (0.31) | ACSS2HDAC1ALDH1A1 | |
| SCHEMBL21391060 | 0.81 | HDAC1 (0.36) | ACSS2TBXA2RCYP11B1CYP11B2HDAC1 | |
| SCHEMBL21391063 | 0.81 | HDAC1 (0.36) | ACSS2TBXA2RCYP11B1CYP11B2HDAC1 | |
| SCHEMBL21390956 | 0.80 | RORC (0.33) | ACSS2HDAC1ALDH1A1 | |
| SCHEMBL21391072 | 0.80 | PDE10A (0.34) | ACSS2TNKSPARP2PARP1CYP11B2 | |
| SCHEMBL17582818 | 0.79 | ALK (0.43) | ACSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |