Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 1/20 | 0.52 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.50 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.50 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.50 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.48 |
| ▸ | HAT1 | O14929 | 1/20 | 0.47 |
| ▸ | EP300 | Q09472 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | FPR2 | P25090 | 1/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18228901 | 1.00 | PYGL (0.52) | PYGLPLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL6967539 | 0.83 | HDAC2 (0.56) | NAALAD2ALDH1A1RECQL | |
| SCHEMBL9001368 | 0.82 | PYGL (0.58) | PYGLPLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL21391858 | 0.82 | FPR2 (0.63) | PYGLPLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL18228675 | 0.82 | FPR2 (0.63) | PYGLPLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL21959116 | 0.80 | FPR2 (0.56) | PYGLPLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL18228915 | 0.80 | FPR2 (0.56) | PYGLPLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL21882747 | 0.79 | HTRA1 (0.60) | — | |
| SCHEMBL18055506 | 0.79 | HTRA1 (0.60) | — | |
| SCHEMBL18228741 | 0.77 | HTRA1 (0.56) | KMT2ANAALAD2CA1CA2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107531653-B | Novel difluoroketoamide derivatives | 豪夫迈·罗氏有限公司 | 2021-10-19 | — | — | CN | disclosed |
| EP-3294718-B1 | NEW DIFLUOROKETAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2020-04-29 | — | — | EP | disclosed |
| US-10428108-B2 | Difluoroketamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2019-10-01 | — | — | US | disclosed |
| CN-107531653-A | Novel difluoroketoamide derivatives | 豪夫迈·罗氏有限公司 | 2018-01-02 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10428108-B2 | Difluoroketamide derivatives | PRMT9, CDK9, FLT3 | PYGL 4762/4885PLAAT3 3563/4885PLAAT5 2394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.