Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.30 |
| ▸ | CDK2 | P24941 | 2/20 | 0.30 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.30 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21392146 | 0.80 | CTPS1 (0.32) | CTPS1 | |
| SCHEMBL21387717 | 0.78 | ALDH1A1 (0.35) | ALDH1A1NPSR1 | |
| SCHEMBL25778800 | 0.78 | CTPS1 (0.49) | CTPS1 | |
| SCHEMBL21392033 | 0.77 | LMNA (0.40) | ALDH1A1NPSR1KMT2A | |
| SCHEMBL21387698 | 0.74 | HTR3A (0.32) | CTPS1 | |
| SCHEMBL21392034 | 0.73 | ABL1 (0.31) | CCNA2CDK2CCNA1 | |
| SCHEMBL21387657 | 0.72 | CTPS1 (0.34) | CTPS1 | |
| SCHEMBL21392186 | 0.71 | CTPS1 (0.33) | CTPS1 | |
| SCHEMBL21387714 | 0.69 | CTPS1 (0.41) | CTPS1 | |
| SCHEMBL21392081 | 0.68 | TAS2R14 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019179652-A1 | AMINOPYRIMIDINE DERIVATIVES AS CTPS1 INHIBITORS | STEP PHARMA S.A.S. (FR) | 2019-09-26 | — | — | WO | disclosed |