Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21387657 | 0.84 | CTPS1 (0.34) | CTPS1 | |
| SCHEMBL21387717 | 0.80 | ALDH1A1 (0.35) | — | |
| SCHEMBL27903061 | 0.77 | MAPK9 (0.39) | MAPK9MAPK10 | |
| SCHEMBL21392186 | 0.75 | CTPS1 (0.33) | CTPS1 | |
| SCHEMBL21392238 | 0.74 | ALDH1A1 (0.32) | CTPS1 | |
| SCHEMBL21387600 | 0.72 | CTPS1 (0.31) | CTPS1 | |
| SCHEMBL21392071 | 0.71 | CTPS1 (0.31) | CTPS1 | |
| SCHEMBL21392033 | 0.71 | LMNA (0.40) | — | |
| SCHEMBL21387693 | 0.69 | SYK (0.43) | CTPS1 | |
| SCHEMBL21391982 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3543232-A1 | AMINOPYRIMIDINE DERIVATIVES AS CTPS1 INHIBITORS | Step Pharma S.A.S. (FR) | 2019-09-25 | — | — | EP | disclosed |