Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 6/20 | 0.63 |
| ▸ | TEAD4 | Q15561 | 6/20 | 0.63 |
| ▸ | MAOB | P27338 | 4/20 | 0.50 |
| ▸ | MAOA | P21397 | 3/20 | 0.50 |
| ▸ | RNF114 | Q9Y508 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | TERT | O14746 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 1/20 | 0.47 |
| ▸ | RXRB | P28702 | 1/20 | 0.47 |
| ▸ | RXRG | P48443 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31574540 | 0.83 | RXRA (0.60) | MAOBMAOARXRARXRBRXRG | |
| SCHEMBL21392773 | 0.78 | YAP1 (1.00) | YAP1TEAD4MAOBMAOARNF114 | |
| SCHEMBL30688878 | 0.71 | RNF114 (0.88) | YAP1TEAD4RNF114KMT2A | |
| SCHEMBL25542768 | 0.69 | YAP1 (0.85) | YAP1TEAD4MAOBMAOANPSR1 | |
| SCHEMBL14659832 | 0.69 | KMT2A (0.69) | YAP1TEAD4NPSR1MEN1KMT2A | |
| SCHEMBL21392919 | 0.68 | YAP1 (0.83) | YAP1TEAD4MAOBMAOARNF114 | |
| SCHEMBL28205908 | 0.66 | NPSR1 (0.74) | MAOBMAOANPSR1MEN1KMT2A | |
| SCHEMBL27918012 | 0.66 | MAOB (0.64) | MAOBMAOANPSR1MEN1KMT2A | |
| SCHEMBL12857635 | 0.65 | HTT (0.73) | YAP1TEAD4MAOBKMT2A | |
| SCHEMBL23052172 | 0.65 | POLB (0.76) | YAP1TEAD4MAOANPSR1RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11666661-B2 | Methods and compounds for targeted autophagy | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2023-06-06 | — | — | US | disclosed |
| US-11666661-B2 | Methods and compounds for targeted autophagy | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2023-06-06 | — | — | US | disclosed |
| US-20210369731-A1 | COVALENT TARGETING OF E3 LIGASES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2021-12-02 | — | — | US | disclosed |
| US-20190290778-A1 | METHODS AND COMPOUNDS FOR TARGETED AUTOPHAGY | FRONTIER MEDICINES CORPORATION | 2019-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190290778-A1 | METHODS AND COMPOUNDS FOR TARGETED AUTOPHAGY | ATG7, BECN1, SQSTM1 | YAP1 1622/4885TEAD4 1748/4885MAOB 3325/4885 |
| US-20210369731-A1 | COVALENT TARGETING OF E3 LIGASES | RNF114, RNF4, RNF168 | YAP1 383/4885TEAD4 1187/4885MAOB 4196/4885 |
| US-11666661-B2 | Methods and compounds for targeted autophagy | ATG7, BECN1, SQSTM1 | YAP1 1622/4885TEAD4 1748/4885MAOB 3325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.