Sugi Predict

Sugi Predict / Compounds / SCHEMBL21392988

SCHEMBL21392988

SCHEMBL21392988

C=CCN(C(=O)C=C)c1cccc2c1CCC2

nearest known ligand 0.43

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ RXRB P28702 10/20 0.43
▸ RXRA P19793 10/20 0.43
▸ RXRG P48443 8/20 0.43
▸ BCL2L1 Q07817 1/20 0.35
▸ BAD Q92934 1/20 0.35
▸ ALDH1A1 P00352 2/20 0.35
▸ MEN1 O00255 2/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ LMNA P02545 1/20 0.34
▸ THRA P10827 1/20 0.34
▸ THRB P10828 1/20 0.34
▸ PPARG P37231 1/20 0.34
▸ HDAC6 Q9UBN7 1/20 0.33
▸ MRGPRX4 Q96LA9 1/20 0.33
▸ BCL2A1 Q16548 1/20 0.33
▸ CXCR5 P32302 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11215834 0.88 RXRB (0.50) RXRBRXRARXRGBCL2L1BAD
SCHEMBL21392983 0.83 RXRB (0.52) RXRBRXRARXRGMRGPRX4BCL2A1
SCHEMBL21392984 0.80 ALDH1A1 (0.42) RXRBRXRARXRGALDH1A1MEN1
SCHEMBL31565004 0.79 RXRA (0.49) RXRBRXRARXRGBCL2L1BAD
SCHEMBL20456630 0.79 RXRA (0.49) RXRBRXRARXRGBCL2L1BAD
SCHEMBL4622662 0.75 RXRB (0.40) RXRBRXRARXRGBCL2L1BAD
SCHEMBL20469871 0.69 RXRA (0.44) RXRBRXRARXRGBCL2L1BAD
SCHEMBL1025407 0.68 RXRB (0.52) RXRBRXRARXRGBCL2L1BAD
SCHEMBL20506904 0.68 BCL2A1 (0.40) ALDH1A1MEN1KMT2ALMNABCL2A1
SCHEMBL21962435 0.67 CXCR5 (0.43) RXRBRXRARXRGBCL2L1BAD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113164495-B Covalent targeting of E3 ligases 加利福尼亚大学董事会 2025-04-22 — — CN disclosed
US-20250120982-A1 COVALENT TARGETING OF E3 LIGASES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2025-04-17 — — US disclosed
US-12161648-B2 Covalent targeting of E3 ligases THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-12-10 — — US disclosed
US-20210369731-A1 COVALENT TARGETING OF E3 LIGASES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2021-12-02 — — US disclosed
US-20210369731-A1 COVALENT TARGETING OF E3 LIGASES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2021-12-02 — — US disclosed
EP-3863642-A1 COVALENT TARGETING OF E3 LIGASES The Regents of the University of California (US) 2021-08-18 — — EP disclosed
CN-113164495-A Covalent targeting of E3 ligase 加利福尼亚大学董事会 2021-07-23 — — CN disclosed
US-20190290778-A1 METHODS AND COMPOUNDS FOR TARGETED AUTOPHAGY FRONTIER MEDICINES CORPORATION 2019-09-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12161648-B2 Covalent targeting of E3 ligases RNF114, RNF4, RNF168 RXRB 2973/4885RXRA 2823/4885RXRG 2484/4885
US-20190290778-A1 METHODS AND COMPOUNDS FOR TARGETED AUTOPHAGY ATG7, BECN1, SQSTM1 RXRB 1975/4885RXRA 2028/4885RXRG 1851/4885
US-20210369731-A1 COVALENT TARGETING OF E3 LIGASES RNF114, RNF4, RNF168 RXRB 2973/4885RXRA 2823/4885RXRG 2484/4885
US-20250120982-A1 COVALENT TARGETING OF E3 LIGASES STUB1, XIAP, RBX1 RXRB 3292/4885RXRA 3146/4885RXRG 3215/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.