Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 4/20 | 0.49 |
| ▸ | OXTR | P30559 | 1/20 | 0.48 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | GRK2 | P25098 | 1/20 | 0.44 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.43 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.43 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.43 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.43 |
| ▸ | SCD | O00767 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29442882 | 1.00 | GAA (0.59) | GAAKDM4EMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL28707397 | 0.85 | MAPT (0.56) | GAAKDM4EMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL13090580 | 0.83 | KDM4E (0.72) | GAAKDM4EMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL30862011 | 0.83 | KDM4E (0.72) | GAAKDM4EMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL28701830 | 0.80 | MAPT (0.58) | GAAKDM4EMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL632349 | 0.80 | EGFR (0.59) | GAAKDM4EMAPTALDH1A1EGFR | |
| SCHEMBL28892293 | 0.79 | OXTR (0.59) | GAAKDM4EMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL26485835 | 0.79 | LMNA (0.67) | MAPTALDH1A1EGFRCYP3A4CYP2C19 | |
| SCHEMBL2908532 | 0.78 | LTA4H (0.66) | GAAKDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL632217 | 0.78 | CHRM2 (0.55) | GAAKDM4EMAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198026-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-10-01 | — | — | WO | disclosed |
| WO-2019183587-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2019-09-26 | — | — | WO | disclosed |