Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 4/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | WNT1 | P04628 | 2/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | CLK3 | P49761 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.44 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | DHX9 | Q08211 | 1/20 | 0.42 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21394681 | 0.93 | SMN1; SMN2 (0.48) | SMN1; SMN2GSK3BDYRK1ACSF1RWNT1 | |
| SCHEMBL21395080 | 0.90 | SMN1; SMN2 (0.50) | SMN1; SMN2GSK3BDYRK1ACSF1RWNT1 | |
| SCHEMBL21394784 | 0.83 | GCK (0.44) | SMN1; SMN2ABCB1ABCC1ALDH1A1KDM4E | |
| SCHEMBL29356925 | 0.83 | GCK (0.44) | SMN1; SMN2ABCB1ABCC1ALDH1A1KDM4E | |
| SCHEMBL29442864 | 0.82 | ALDH1A1 (0.50) | GSK3BDYRK1ACSF1RWNT1ALDH1A1 | |
| SCHEMBL21394827 | 0.82 | ALDH1A1 (0.50) | GSK3BDYRK1ACSF1RWNT1ALDH1A1 | |
| SCHEMBL21394395 | 0.81 | KDM4E (0.49) | SMN1; SMN2ABCB1ABCC1ALDH1A1KDM4E | |
| SCHEMBL21395156 | 0.81 | KDM4E (0.42) | SMN1; SMN2ABCB1ABCC1ALDH1A1KDM4E | |
| SCHEMBL21394958 | 0.81 | P2RX3 (0.42) | SMN1; SMN2ABCB1ABCC1ALDH1A1KDM4E | |
| SCHEMBL21395009 | 0.80 | PARP1 (0.53) | SMN1; SMN2ABCB1ABCC1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198026-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-10-01 | — | — | WO | disclosed |
| WO-2019183587-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2019-09-26 | — | — | WO | disclosed |