Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 10/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21394754 | 0.90 | NPC1 (0.46) | GRM5KDM4ENPC1RAB9AWNT3A | |
| SCHEMBL29358598 | 0.90 | NPC1 (0.46) | GRM5KDM4ENPC1RAB9AWNT3A | |
| SCHEMBL21394469 | 0.82 | SNCA (0.48) | GRM5NPC1RAB9AWNT3A | |
| SCHEMBL21394920 | 0.82 | ALDH1A1 (0.49) | KDM4ECYP1A2CYP2C9CYP3A4NPC1 | |
| SCHEMBL29442811 | 0.82 | SNCA (0.48) | GRM5NPC1RAB9AWNT3A | |
| SCHEMBL21394918 | 0.81 | GRM5 (0.43) | GRM5KDM4ECYP1A2CYP2C9KCNH2 | |
| SCHEMBL21394395 | 0.80 | KDM4E (0.49) | GRM5KDM4ENPC1RAB9A | |
| SCHEMBL21394572 | 0.79 | TSHR (0.44) | GRM5KDM4ENPC1RAB9A | |
| SCHEMBL29357109 | 0.79 | TSHR (0.44) | GRM5KDM4ENPC1RAB9A | |
| SCHEMBL21394947 | 0.79 | JUN (0.43) | GRM5NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198026-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-10-01 | — | — | WO | disclosed |
| WO-2019183587-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2019-09-26 | — | — | WO | disclosed |