Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
| ▸ | SCN4A | P35499 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26945217 | 0.85 | ALDH1A1 (0.56) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL5502180 | 0.83 | ALDH1A1 (0.50) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL5497733 | 0.71 | HPGD (0.56) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL13497792 | 0.71 | FABP4 (0.45) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL3894930 | 0.71 | LIPC (0.66) | ALDH1A1MAPTHPGDCYP2C19GAA | |
| SCHEMBL21166537 | 0.70 | STAT3 (0.44) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL13497790 | 0.70 | CYP1A2 (0.44) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL5265322 | 0.70 | LIPC (0.50) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL14015041 | 0.69 | VDR (0.45) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL13498234 | 0.69 | CCR2 (0.42) | MEN1KMT2ALMNAPKMCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2019-10-02 | — | — | EP | disclosed |