Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 5/20 | 0.48 |
| ▸ | PFKFB4 | Q16877 | 2/20 | 0.48 |
| ▸ | EDNRB | P24530 | 1/20 | 0.46 |
| ▸ | EDNRA | P25101 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | GHSR | Q92847 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21426944 | 0.77 | PFKFB3 (0.52) | PFKFB3PFKFB4EDNRBEDNRAMAPT | |
| SCHEMBL21427082 | 0.75 | PFKFB3 (0.45) | PFKFB3PFKFB4EDNRBEDNRAMAPT | |
| SCHEMBL4631538 | 0.73 | EDNRA (0.83) | EDNRBEDNRA | |
| SCHEMBL28291689 | 0.72 | MMP2 (0.46) | PFKFB3PFKFB4EDNRBEDNRAMAPT | |
| SCHEMBL4632351 | 0.70 | EDNRB (0.56) | PFKFB3PFKFB4EDNRBEDNRAMAPT | |
| SCHEMBL14569173 | 0.70 | PTGS2 (0.43) | PFKFB3PFKFB4KMT2AMMP2MMP9 | |
| SCHEMBL3254332 | 0.69 | MMP2 (0.42) | PFKFB3PFKFB4EDNRBEDNRAKMT2A | |
| SCHEMBL13743183 | 0.69 | CA2 (0.56) | PFKFB3PFKFB4MMP2MMP9 | |
| SCHEMBL7549393 | 0.69 | MMP2 (0.42) | PFKFB3PFKFB4EDNRBEDNRAKMT2A | |
| SCHEMBL14415019 | 0.68 | HCAR2 (0.38) | ALDH1A1LMNAHPGDALOX15HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210077562-A1 | ETBR ANTAGONIST COMPOUNDS, COMPOSITIONS, AND USES | ENB THERAPEUTICS, INC. | 2021-03-18 | — | — | US | disclosed |
| US-20190314444-A1 | ETBR ANTAGONIST COMPOUNDS, COMPOSITIONS, AND USES | ENB THERAPEUTICS, INC. | 2019-10-17 | — | — | US | disclosed |
| WO-2019191721-A1 | ETBR ANTAGONIST COMPOUNDS, COMPOSITIONS, AND USES | ENB THERAPEUTICS, INC. (US) | 2019-10-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190314444-A1 | ETBR ANTAGONIST COMPOUNDS, COMPOSITIONS, AND USES | EDNRB, EDNRA, LTB4R | PFKFB3 3747/4885PFKFB4 3617/4885EDNRB 1/4885 |
| US-20210077562-A1 | ETBR ANTAGONIST COMPOUNDS, COMPOSITIONS, AND USES | EDNRB, EDNRA, LTB4R | PFKFB3 3747/4885PFKFB4 3617/4885EDNRB 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.