Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.73 |
| ▸ | PARP1 | P09874 | 1/20 | 0.67 |
| ▸ | EGLN1 | Q9GZT9 | 15/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | GMNN | O75496 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | CCR1 | P32246 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27872555 | 0.86 | ALDH1A1 (0.77) | ALDH1A1PARP1EGLN1KDM4EGMNN | |
| SCHEMBL1759043 | 0.84 | ALDH1A1 (1.00) | ALDH1A1EGLN1KDM4ELMNATP53 | |
| SCHEMBL9139640 | 0.83 | ALDH1A1 (0.97) | ALDH1A1EGLN1KDM4ELMNATP53 | |
| SCHEMBL253460 | 0.83 | ALDH1A1 (0.73) | ALDH1A1EGLN1 | |
| SCHEMBL2143864 | 0.83 | ALDH1A1 (0.73) | ALDH1A1EGLN1KDM4EGMNNLMNA | |
| SCHEMBL8885906 | 0.83 | ALDH1A1 (0.73) | ALDH1A1EGLN1KDM4EGMNNLMNA | |
| SCHEMBL12647755 | 0.82 | ALDH1A1 (0.67) | ALDH1A1EGLN1KDM4EHSP90AA1 | |
| SCHEMBL27575008 | 0.82 | PARP1 (0.60) | ALDH1A1PARP1EGLN1KDM4EGMNN | |
| SCHEMBL29923346 | 0.80 | PARP1 (1.00) | ALDH1A1PARP1KDM4ELMNAMMP2 | |
| SCHEMBL29959688 | 0.80 | PARP1 (1.00) | ALDH1A1PARP1KDM4ELMNAMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326865-A2 | AZA- AND POLYAZA-NAPHTHALENYL CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2003-07-16 | — | — | EP | claimed |
| US-20030055071-A1 | Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors | MERCK SHARP & DOHME CORP. | 2003-03-20 | — | — | US | claimed |
| WO-2002030930-A2 | AZA- AND POLYAZA-NAPHTHALENYL CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 2002-04-18 | — | — | WO | claimed |
| CN-105384685-A | New tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof | POLICHEM SA | 2016-03-09 | — | — | CN | disclosed |
| CN-105384685-A | New tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof | POLICHEM SA | 2016-03-09 | — | — | CN | disclosed |
| CN-105384685-A | New tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof | POLICHEM SA | 2016-03-09 | — | — | CN | disclosed |
| CN-105168213-A | Secondary 8-hydroxyquinoline-7-carboxamide derivatives for use as antifungal agents | POLICHEM SA | 2015-12-23 | — | — | CN | disclosed |
| CN-105168213-A | Secondary 8-hydroxyquinoline-7-carboxamide derivatives for use as antifungal agents | POLICHEM SA | 2015-12-23 | — | — | CN | disclosed |
| CN-105168213-A | Secondary 8-hydroxyquinoline-7-carboxamide derivatives for use as antifungal agents | POLICHEM SA | 2015-12-23 | — | — | CN | disclosed |
| EP-2519505-B1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2015-05-27 | — | — | EP | disclosed |
| US-8969380-B2 | Secondary 8-hydroxyquinoline-7-carboxamide derivatives for use as antifungal agents | POLICHEM SA (LU) | 2015-03-03 | — | — | US | disclosed |
| EP-0927164-A1 | 8-HYDROXY-7-SUBSTITUTED QUINOLINES AS ANTI-VIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 1999-07-07 | — | — | EP | disclosed |
| WO-1998011073-A1 | 8-HYDROXY-7-SUBSTITUTED QUINOLINES AS ANTI-VIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 1998-03-19 | — | — | WO | disclosed |
| US-4812565-A | ANTIHISTAMINE INTERMEDIATES | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-03-14 | — | — | US | disclosed |
| US-4810795-A | ANTIHISTAMINES | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-03-07 | — | — | US | disclosed |
| US-4727152-A | Intermediates useful in the preparation of fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof | A. H. ROBINS COMPANY, INC. (US) | 1988-02-23 | — | — | US | disclosed |
| US-4705853-A | ANTIHISTAMINES | A. H. ROBINS COMPANY, INC. (US) | 1987-11-10 | — | — | US | disclosed |
| US-4642343-A | ANTIHISTAMINES | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-02-10 | — | — | US | disclosed |
| US-4604388-A | Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof in a method of counteracting histamine | A. H. ROBINS COMPANY, INCORPORATED (US) | 1986-08-05 | — | — | US | disclosed |
| US-4592866-A | Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof | A. H. ROBINS COMPANY, INC. (US) | 1986-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030055071-A1 | Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors | POLI, DUT, NAAA | ALDH1A1 2855/4885PARP1 20/4885EGLN1 2027/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.