Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 3/20 | 0.38 |
| ▸ | CCND1 | P24385 | 3/20 | 0.38 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.37 |
| ▸ | NPY4R | P50391 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28835530 | 0.80 | TSHR (0.60) | TSHRRAB9AL3MBTL1NOTUMKMT2A | |
| SCHEMBL9654115 | 0.79 | L3MBTL1 (0.69) | TSHRRAB9AL3MBTL1NOTUMKMT2A | |
| SCHEMBL28529485 | 0.76 | RAB9A (0.60) | TSHRRAB9AL3MBTL1NOTUMKMT2A | |
| SCHEMBL21777692 | 0.76 | TSHR (0.60) | TSHRRAB9AL3MBTL1NOTUMLMNA | |
| SCHEMBL29494636 | 0.76 | RAB9A (0.60) | TSHRRAB9AL3MBTL1NOTUMKMT2A | |
| SCHEMBL28864285 | 0.76 | TSHR (0.60) | TSHRRAB9AL3MBTL1NOTUMKMT2A | |
| SCHEMBL8447109 | 0.76 | RAB9A (0.60) | TSHRRAB9AL3MBTL1NOTUMKMT2A | |
| SCHEMBL28921429 | 0.76 | L3MBTL1 (0.60) | TSHRRAB9AL3MBTL1NOTUMKMT2A | |
| SCHEMBL9655173 | 0.73 | L3MBTL1 (0.59) | TSHRRAB9AL3MBTL1NOTUMKMT2A | |
| SCHEMBL28244321 | 0.73 | TSHR (0.55) | TSHRRAB9AL3MBTL1NOTUMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3773563-A1 | PRODRUGS OF FUSED-BICYCLIC C5AR ANTAGONISTS | ChemoCentryx, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| WO-2019195159-A1 | PRODRUGS OF FUSED-BICYCLIC C5aR ANTAGONISTS | CHEMOCENTRYX, INC. (US) | 2019-10-10 | — | — | WO | disclosed |