Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 9/20 | 0.75 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | NSD2 | O96028 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16735597 | 0.89 | EGLN1 (0.77) | EGLN1MAPTLMNA | |
| SCHEMBL2144304 | 0.89 | EGLN1 (0.60) | EGLN1MAPTLMNAHPGDL3MBTL1 | |
| SCHEMBL2353779 | 0.89 | EGLN1 (0.60) | EGLN1MAPTLMNAKMT2ARPS6KB1 | |
| SCHEMBL2291211 | 0.88 | EGLN1 (0.76) | EGLN1KMT2A | |
| SCHEMBL16735679 | 0.86 | EGLN1 (0.57) | EGLN1MAPTLMNAHPGDL3MBTL1 | |
| SCHEMBL2200760 | 0.86 | EGLN1 (1.00) | EGLN1MAPTNSD2MAPK8ATM | |
| SCHEMBL2296475 | 0.83 | EGLN1 (0.53) | EGLN1MAPTHPGDL3MBTL1ADORA2A | |
| SCHEMBL6983554 | 0.83 | EGLN1 (0.76) | EGLN1MAPTNSD2LMNAGAA | |
| SCHEMBL16735665 | 0.82 | EGLN1 (0.74) | EGLN1MAPTGAAL3MBTL1KMT2A | |
| SCHEMBL2294722 | 0.81 | HPGD (0.59) | EGLN1MAPTLMNAHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519505-A1 | NEW TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | Polichem SA (LU) | 2012-11-07 | — | — | EP | claimed |
| EP-2345643-A1 | New tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof | POLICHEM S.A. (LU) | 2011-07-20 | — | — | EP | claimed |
| WO-2011080264-A1 | NEW TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM S.A. (LU) | 2011-07-07 | — | — | WO | claimed |