Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 4/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2202703 | 0.87 | EGLN1 (0.66) | HPGDALDH1A1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL2144302 | 0.81 | EGLN1 (0.75) | HPGDLMNAMAPTKMT2AEGLN1 | |
| SCHEMBL2144304 | 0.78 | EGLN1 (0.60) | HPGDLMNAMAPTKMT2AEGLN1 | |
| SCHEMBL2353779 | 0.78 | EGLN1 (0.60) | SMN1; SMN2LMNAMAPTKMT2AEGLN1 | |
| SCHEMBL16735597 | 0.78 | EGLN1 (0.77) | ALDH1A1LMNAMAPTEGLN1TSHR | |
| SCHEMBL2296475 | 0.77 | EGLN1 (0.53) | HPGDALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL16735679 | 0.76 | EGLN1 (0.57) | HPGDLMNAMAPTKMT2AEGLN1 | |
| SCHEMBL15662000 | 0.75 | PSMD14 (0.85) | HPGDALDH1A1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL2291211 | 0.74 | EGLN1 (0.76) | SMN1; SMN2HSD17B10MEN1KMT2AEGLN1 | |
| SCHEMBL23412428 | 0.74 | HPGD (0.72) | HPGDALDH1A1SMN1; SMN2LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519505-B1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2015-05-27 | — | — | EP | claimed |
| EP-2519505-A1 | NEW TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | Polichem SA (LU) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080264-A1 | NEW TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM S.A. (LU) | 2011-07-07 | — | — | WO | disclosed |