Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 6/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | GALR3 | O60755 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4573203 | 1.00 | ALOX15 (0.38) | ALOX15CASP1ERN1HPGDTSHR | |
| SCHEMBL3934466 | 0.81 | TYR (0.54) | ALOX15TSHRMAPTKMT2AHTT | |
| SCHEMBL5024409 | 0.78 | HPGD (0.42) | ALOX15CASP1ERN1HPGDTSHR | |
| SCHEMBL1897113 | 0.77 | ERN1 (0.47) | ALOX15CASP1ERN1HPGDTSHR | |
| SCHEMBL472482 | 0.77 | GABRA1 (0.50) | ALOX15ERN1HPGDMAPTGAA | |
| SCHEMBL4573344 | 0.75 | MAPT (0.38) | ALOX15CASP1ERN1HPGDMAPT | |
| SCHEMBL9154085 | 0.73 | ALOX15 (0.48) | ALOX15CASP1ERN1HPGDTSHR | |
| SCHEMBL7012686 | 0.72 | HSPA5 (0.50) | ALOX15HPGDTSHRMAPTLMNA | |
| SCHEMBL2186993 | 0.72 | HPGD (0.58) | HPGDTSHRMAPTGAAKMT2A | |
| SCHEMBL722485 | 0.71 | ALOX12 (0.33) | ALOX15HPGDMAPTGAAALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344494-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | Signal Pharmaceuticals, LLC (US) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010027500-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2010-03-11 | — | — | WO | disclosed |