Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | GALR3 | O60755 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.33 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 3/20 | 0.33 |
| ▸ | MAOB | P27338 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4573203 | 0.75 | ALOX15 (0.38) | MAPTKMT2AKDM4EPOLBGAA | |
| SCHEMBL2144792 | 0.75 | ALOX15 (0.38) | MAPTKMT2AKDM4EPOLBGAA | |
| SCHEMBL1897113 | 0.71 | ERN1 (0.47) | HPGDHTTCES2GALR3CYP1A2 | |
| SCHEMBL9900604 | 0.71 | THRB (0.37) | MAPTKMT2AKDM4EPOLBHPGD | |
| SCHEMBL9900406 | 0.70 | PTPN1 (0.41) | MAPTKDM4EPOLBGAACASP1 | |
| SCHEMBL15658116 | 0.70 | MAPT (0.46) | MAPTPOLBGAAHPGDCES2 | |
| SCHEMBL30777878 | 0.69 | ALOX15 (0.44) | KDM4EPOLBGAAHPGDHTT | |
| SCHEMBL1005997 | 0.69 | ALOX15 (0.44) | KDM4EPOLBGAAHPGDHTT | |
| SCHEMBL2450978 | 0.68 | HTT (0.36) | KMT2AHPGDHTTCYP2C9CYP2C19 | |
| SCHEMBL472482 | 0.68 | GABRA1 (0.50) | MAPTKMT2AKDM4EPOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |