Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL28610359 | 0.81 | ALDH1A1 (0.45) | LRRK2ALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL26797380 | 0.77 | LRRK2 (0.52) | LRRK2ALDH1A1CYP1A2PIK3CAPIK3R1 | |
| SCHEMBL2711245 | 0.76 | KDM4E (0.43) | LRRK2ALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL6854811 | 0.75 | LGMN (0.47) | ALDH1A1MEN1KMT2AHSD17B10USP2 | |
| SCHEMBL17583342 | 0.72 | KDM4E (0.57) | LRRK2ALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL30622679 | 0.72 | KDM4E (0.57) | LRRK2ALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL3723928 | 0.72 | ALDH1A1 (0.54) | ALDH1A1MEN1KMT2AHSD17B10USP2 | |
| Hydrochloric Acid SCHEMBL10887133 | 0.71 | PIK3CA (0.48) | LRRK2ALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL10076882 | 0.70 | KDM4E (0.47) | LRRK2ALDH1A1CYP1A2PIK3CAPIK3R1 | |
| SCHEMBL16856929 | 0.70 | GAA (0.44) | LRRK2ALDH1A1CYP1A2PIK3CAPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344494-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | Signal Pharmaceuticals, LLC (US) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010027500-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2010-03-11 | — | — | WO | disclosed |