Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 5/20 | 0.39 |
| ▸ | ACHE | P22303 | 5/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | TYMS | P04818 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2144895 | 0.84 | BACE1 (0.42) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL21596925 | 0.76 | DYRK1A (0.44) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL21596926 | 0.72 | MEN1 (0.48) | MEN1KMT2AKDM4EALDH1A1RAB9A | |
| SCHEMBL7369313 | 0.72 | MAP4K4 (0.40) | ADORA2AIDO1DYRK1A | |
| SCHEMBL25171022 | 0.71 | ALDH1A1 (0.44) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL4019162 | 0.71 | MEN1 (0.66) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL1013979 | 0.70 | ALDH1A1 (0.44) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL3846806 | 0.68 | MEN1 (0.67) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL21596922 | 0.68 | KMT2A (0.50) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL21596941 | 0.68 | NPC1 (0.48) | KDM4ERAB9APIM1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3810602-A1 | COMPOUNDS | CTXT Pty Limited (AU) | 2021-04-28 | — | — | EP | disclosed |
| WO-2019243491-A1 | COMPOUNDS | CTXT PTY LIMITED (AU) | 2019-12-26 | — | — | WO | disclosed |
| EP-2344494-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | Signal Pharmaceuticals, LLC (US) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010027500-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2010-03-11 | — | — | WO | disclosed |