Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | CHUK | O15111 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21451895 | 0.88 | KDM4E (0.35) | KDM4EALDH1A1 | |
| SCHEMBL19730012 | 0.74 | LMNA (0.43) | ALDH1A1FFAR1 | |
| SCHEMBL21451648 | 0.71 | PTPN1 (0.36) | KDM4E | |
| SCHEMBL21451653 | 0.70 | KMT2A (0.33) | KDM4EALDH1A1 | |
| SCHEMBL21451937 | 0.68 | KDM4E (0.39) | KDM4EALDH1A1 | |
| SCHEMBL19730107 | 0.66 | CYP11B1 (0.45) | — | |
| SCHEMBL27848193 | 0.60 | USP2 (0.36) | FFAR4KDM4EALDH1A1FFAR1 | |
| SCHEMBL21452070 | 0.59 | — | — | |
| SCHEMBL8486599 | 0.55 | FFAR1 (0.36) | HDAC6FFAR4ALDH1A1FFAR1 | |
| SCHEMBL15229716 | 0.55 | HDAC6 (0.52) | HDAC6KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10918645-B2 | Substituted tricyclic heterocyclic compounds and use thereof | LIFEARC (GB) | 2021-02-16 | — | — | US | disclosed |
| US-20190307763-A1 | SUBSTITUTED TRICYCLIC HETEROCYCLIC COMPOUNDS AND USE THEREOF | LIFEARC (GB) | 2019-10-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10918645-B2 | Substituted tricyclic heterocyclic compounds and use thereof | MAPT, TTBK1, TNK2 | HDAC6 210/4885FFAR4 2830/4885KDM4E 3760/4885 |
| US-20190307763-A1 | SUBSTITUTED TRICYCLIC HETEROCYCLIC COMPOUNDS AND USE THEREOF | MAPT, NNMT, TKFC | HDAC6 168/4885FFAR4 2571/4885KDM4E 3987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.