Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | CCR4 | P51679 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | BUB1 | O43683 | 2/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31500890 | 1.00 | CYP11B1 (0.45) | CYP11B1CYP11B2JAK2PTGER4CNR1 | |
| SCHEMBL19730012 | 0.92 | LMNA (0.43) | CYP11B1CYP11B2JAK2PTGER4CNR1 | |
| SCHEMBL415781 | 0.88 | CYP11B1 (0.47) | CYP11B1CYP11B2JAK2PTGER4CNR1 | |
| SCHEMBL3777337 | 0.85 | JAK2 (0.49) | CYP11B1CYP11B2JAK2P2RX3POLB | |
| SCHEMBL883468 | 0.85 | JAK2 (0.48) | CYP11B1CYP11B2JAK2 | |
| SCHEMBL19730053 | 0.79 | CNR1 (0.43) | JAK2PTGER4CNR1CNR2CCR4 | |
| SCHEMBL444498 | 0.78 | LMNA (0.45) | PTGER4CNR1CNR2LMNA | |
| SCHEMBL3781866 | 0.78 | JAK2 (0.49) | JAK2POLBRXFP1LMNA | |
| SCHEMBL19730136 | 0.77 | JAK2 (0.39) | JAK2PTGER4CNR1CNR2CCR4 | |
| SCHEMBL21434366 | 0.77 | JAK2 (0.39) | JAK2PTGER4CNR1CNR2CCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10918645-B2 | Substituted tricyclic heterocyclic compounds and use thereof | LIFEARC (GB) | 2021-02-16 | — | — | US | disclosed |
| US-20190307763-A1 | SUBSTITUTED TRICYCLIC HETEROCYCLIC COMPOUNDS AND USE THEREOF | LIFEARC (GB) | 2019-10-10 | — | — | US | disclosed |
| WO-2017215600-A1 | SUBSTITUTED TRICYCLIC HERTEOCYCLIC COMPOUNDS AND USE THEREOF | SUZHOU YABAO PHARMACEUTICAL R&D CO., LTD. (CN) | 2017-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10918645-B2 | Substituted tricyclic heterocyclic compounds and use thereof | MAPT, TTBK1, TNK2 | CYP11B1 81/4885CYP11B2 105/4885JAK2 1723/4885 |
| US-20190307763-A1 | SUBSTITUTED TRICYCLIC HETEROCYCLIC COMPOUNDS AND USE THEREOF | MAPT, NNMT, TKFC | CYP11B1 17/4885CYP11B2 35/4885JAK2 1422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.