SCHEMBL21453490

SCHEMBL21453490

c1ccc2c(c1)c1ccccc1c1cc(-c3ccc4c(c3)c3cccc5c6ccccc6c6cccc7sc8cccc(c8c76)n4c53)ccc21

nearest known ligand 0.30

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.30
MEN1 O00255 1/20 0.30
ALDH1A1 P00352 1/20 0.30
POLB P06746 1/20 0.30
MAPT P10636 1/20 0.30
HPGD P15428 1/20 0.30
HTT P42858 1/20 0.30
KMT2A Q03164 1/20 0.30
GPR3 P46089 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21453491 0.97
SCHEMBL21454251 0.96 ALDH1A1 (0.33) KDM4EMEN1ALDH1A1POLBMAPT
SCHEMBL26286688 0.96 ALDH1A1 (0.33) KDM4EMEN1ALDH1A1POLBMAPT
SCHEMBL21453624 0.94 ALDH1A1 (0.36) ALDH1A1MAPTHPGDGPR3
SCHEMBL21453794 0.94 TSPO (0.32) KDM4EMEN1ALDH1A1POLBMAPT
SCHEMBL21453775 0.94 TSPO (0.34)
SCHEMBL21453617 0.92 GPR3 (0.35) ALDH1A1MAPTHPGDGPR3
SCHEMBL21454246 0.91 TSPO (0.33)
SCHEMBL21453833 0.91 TSPO (0.30)
SCHEMBL21454110 0.90 HSD17B1 (0.35) ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11038121-B2 9 membered ring carbazole compounds Beijing Summer Sprout Technology Co., Ltd. (CN) 2021-06-15 US disclosed
US-20190312214-A1 9 MEMBERED RING CARBAZOLE COMPOUNDS BEIJING SUMMER SPROUT TECHNOLOGY CO., LTD (CN) 2019-10-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11038121-B2 9 membered ring carbazole compounds SLC25A21, OCIAD2, OXA1L KDM4E 3723/4885MEN1 4538/4885ALDH1A1 802/4885
US-20190312214-A1 9 MEMBERED RING CARBAZOLE COMPOUNDS SLC25A21, OCIAD2, OXA1L KDM4E 3723/4885MEN1 4538/4885ALDH1A1 802/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.