Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2145473 | 0.88 | GAA (0.51) | TBXAS1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL2145517 | 0.86 | MAPK1 (0.56) | TBXAS1MEN1KMT2ALMNAPKM | |
| SCHEMBL2145752 | 0.86 | NSD2 (0.49) | TBXAS1SMN1; SMN2HTTGAAPARP10 | |
| SCHEMBL2145277 | 0.84 | NSD2 (0.51) | TBXAS1ALDH1A1PARP10KDM4EPARP15 | |
| SCHEMBL2145612 | 0.83 | TBXAS1 (0.52) | TBXAS1MEN1KMT2ALMNAPKM | |
| SCHEMBL2145870 | 0.80 | MAPK1 (0.57) | TBXAS1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL2145861 | 0.80 | L3MBTL1 (0.52) | TBXAS1MEN1KMT2ALMNAPKM | |
| SCHEMBL2145878 | 0.79 | RXFP1 (0.48) | TBXAS1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL2145351 | 0.77 | NSD2 (0.49) | TBXAS1ALDH1A1 | |
| SCHEMBL2145585 | 0.72 | MAPK1 (0.54) | TBXAS1LMNASMN1; SMN2HTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2040702-B1 | USE OF AMPK-ACTIVATING IMIDAZOLE DERIVATIVES, PREPARATION PROCESS THEREFOR AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | MERCK PATENT GMBH (DE) | 2011-07-27 | — | — | EP | claimed |