Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 3/20 | 0.46 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.43 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2145473 | 0.89 | GAA (0.51) | L3MBTL1CNOT7NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2145878 | 0.87 | RXFP1 (0.48) | NPC1RAB9ASMN1; SMN2LMNAGAA | |
| SCHEMBL2145351 | 0.85 | NSD2 (0.49) | ALDH1A1TBXAS1LTA4H | |
| SCHEMBL2145876 | 0.84 | NPC1 (0.47) | L3MBTL1NPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL2145870 | 0.83 | MAPK1 (0.57) | L3MBTL1NPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL2145709 | 0.80 | TBXAS1 (0.51) | L3MBTL1SMN1; SMN2TSHRLMNAALOX15 | |
| SCHEMBL2145752 | 0.75 | NSD2 (0.49) | NPC1RAB9ASMN1; SMN2GAAHTT | |
| SCHEMBL2145646 | 0.74 | GAA (0.51) | L3MBTL1CNOT7NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2146055 | 0.74 | RAB9A (0.45) | L3MBTL1CNOT7NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2145277 | 0.73 | NSD2 (0.51) | ALDH1A1TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2040702-B1 | USE OF AMPK-ACTIVATING IMIDAZOLE DERIVATIVES, PREPARATION PROCESS THEREFOR AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | MERCK PATENT GMBH (DE) | 2011-07-27 | — | — | EP | claimed |