Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 1/20 | 0.49 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.49 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 2/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MMP3 | P08254 | 2/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.41 |
| ▸ | EIF4EBP1 | Q13541 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2145277 | 0.89 | NSD2 (0.51) | NSD2NSD3TBXAS1MMP2KCNA5 | |
| SCHEMBL2145861 | 0.85 | L3MBTL1 (0.52) | TBXAS1ALDH1A1LTA4H | |
| SCHEMBL2146065 | 0.84 | GABRA1 (0.48) | NSD2NSD3TBXAS1MMP2KCNA5 | |
| SCHEMBL2145878 | 0.84 | RXFP1 (0.48) | NSD2NSD3TBXAS1ALDH1A1 | |
| SCHEMBL2145870 | 0.80 | MAPK1 (0.57) | TBXAS1ALDH1A1MAPT | |
| SCHEMBL2145709 | 0.77 | TBXAS1 (0.51) | TBXAS1ALDH1A1 | |
| SCHEMBL2145381 | 0.76 | NSD2 (0.51) | NSD2NSD3TBXAS1MMP2KCNA5 | |
| SCHEMBL2145655 | 0.76 | HRH2 (0.45) | NSD2NSD3TBXAS1MMP2KCNA5 | |
| SCHEMBL2145473 | 0.75 | GAA (0.51) | TBXAS1ALDH1A1LTA4H | |
| SCHEMBL2145204 | 0.74 | GABRA1 (0.43) | NSD2NSD3TBXAS1MMP2KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2040702-B1 | USE OF AMPK-ACTIVATING IMIDAZOLE DERIVATIVES, PREPARATION PROCESS THEREFOR AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | MERCK PATENT GMBH (DE) | 2011-07-27 | — | — | EP | claimed |