Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | NSD2 | O96028 | 1/20 | 0.47 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2145752 | 0.88 | NSD2 (0.49) | RXFP1NSD2NSD3IDO1NPC1 | |
| SCHEMBL2145861 | 0.87 | L3MBTL1 (0.52) | NPC1RAB9ATBXAS1SMN1; SMN2HTT | |
| SCHEMBL2145351 | 0.84 | NSD2 (0.49) | NSD2NSD3TBXAS1ALDH1A1 | |
| SCHEMBL2145448 | 0.84 | NPC1 (0.49) | RXFP1NSD2NSD3NPC1RAB9A | |
| SCHEMBL2145870 | 0.82 | MAPK1 (0.57) | NPC1RAB9ATBXAS1SMN1; SMN2HTT | |
| SCHEMBL2145709 | 0.79 | TBXAS1 (0.51) | TBXAS1SMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL2145473 | 0.77 | GAA (0.51) | NPC1RAB9ATBXAS1SMN1; SMN2HTT | |
| SCHEMBL2145545 | 0.75 | NSD2 (0.49) | RXFP1NSD2NSD3IDO1NPC1 | |
| SCHEMBL2145421 | 0.73 | ALDH1A1 (0.42) | RXFP1NSD2NSD3NPC1RAB9A | |
| SCHEMBL2145876 | 0.73 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2040702-B1 | USE OF AMPK-ACTIVATING IMIDAZOLE DERIVATIVES, PREPARATION PROCESS THEREFOR AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | MERCK PATENT GMBH (DE) | 2011-07-27 | — | — | EP | claimed |